Would it hurt the engine at all if I disconnected one possibly two fuel injectors while driving? If so what would it hurt? I have my reasons for now. Just two tired to explain them.

Sure... it will mess up the A/F ratio. The O2 sensors will "see" all the air that is passing through the non-firing cylinders, think that bank is running super lean, and pour exta fuel in to overcome a non-existant lean condition. Probably enough to foul the plugs in the cylinders that still have the injectors, and maybe enough to wash the lubrication off the cylinder walls and destroy the rings. then the excess fuel, plus the huge amount of air will combust on the cat and melt it, plugging up the exhaust.

Other than that, you'll be fine

To overcome this problem, you could just force it to stay in open loop. I think there are multiple sensors you could unplug to cause that. The most obvious is the O2 itself.

OP - did you make a bet with a mustang driver that you could beat him with 6 cylinders? If you run it hard with nonfiring cylinders you'll probably damage the engine.

I forgot to mention I wanted to keep it in open loop and was planning on disconnecting the O2 sensors. This should definantly keep it in open loop right? Is it bad to keep it in open loop or does the engine just tend to let it run a little richer?