Ok heres the deal, I have had the low rpm stumble and hesitation for 2 years now. I have replaced a ton of stuff (list too long to get into) and checked about everything that I could. At least every month sometimes 2 months I get the service engine soon light and it is always the same thing,

P1416 secondary air system (bank 2)
P0300 random/multiple cylinder misfire detected

I clear the codes and a month or 2 later they pop up again. My question is, is there a relation between the both as to why they show up at the same time? And would either have anything to do with the stumble, hesitation problem I am cursed with.