Okay here is the deal. I have a high RPM mis and today I had a low RPM mis for just a second. When I down shift into second and WOT it stumbles bad but if I down shift into second and wait and second and then punch it it does better? If my coil is sort loose would that cause any problems? ANY advise. I have replace wire, plugs, coil...

 

If you coil is "loose" tighten it, Try to explore other methods first, but those are classic signs of an opti. If it JUST had the high rpm miss I would say it was coil or plugs, but you mentioned the low rpm miss as well and stumbling. Seems like thats a classic sign...