I used to have a high-compression engine while supercharged, all of about 1 month!!!

 

mine is over 2 months know and is still running strong. but i dont keeep my foot to the floor all the time eather. only when a ford is trying to pass lol
Shane

 

a guy that used to post here a few years back James 007 had 11.0:1 lt4 heads/intake/solid roller set up. The car was a 6 speed and ran into high 11s full weight. Dynoed like 430ish rwhp. He slaped a D1SC on it with 12# and was runnning cam2 all the time. The car layed down 640rwhp and over 700rwtrq.
Is it possible to run high comp. with boost? yes but you have to know what you doing, Also be good idea to look into DFI cuz tunning on something like that is goign to make a huge difference.