Is it possible to tune out o2 sensors, and just run a pre-setup program so it runs like a car with o2s?

 

If you do a speed density tune then I believe that the 02 sensors are not used

 

not true, his car is a SD car its a 93.. we use the O2s for our fuel tables

 

yes it is possible.
depending on how much you want to spend on a management system, you can tune the car to run and have it disregard the o2's
ecu's like fast and BS3 allow for that, but they are $2000+

im not sure if there is a way to disable o2 feedback with a stock ecu hack.

 

You don't need an aftermarket ECU.... You can run the stock ECM in "open loop". That's when the O2 sensors are ignored. There are several ways to keep it in open loop. Just make sure you have a very good tune, and that you don't change anything without updating the tune.

Spped-density has nothing to do with whether the O2 sensors are used or not.