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Didn't really do a before and after comparison, but with the HOTcam, ported heads and stall I got about 22 mpg. 3/4 of that was on the interstate, and 1/4 was in stop and go driving.
It really depends on how hot the cam is, but if your that worried about losing 2 mpg, you shouldn't really be looking at a camshaft swap as your next mod.